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Capsaicin and Pain

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Different types of mechanical, chemical and metabolic injuries may damage peripheral nerves and produce impairments in sensory, motor and autonomic functions. Transection of peripheral nerves results in neurotmesis, the most severe form of nerve injury characterized by a complete division of the nerve, which may be associated with neuropathic pain and related painful dysaesthesias. It was suggested that both the axotomy- and the perineural capsaicin treatment-induced reductions in the sensitivity of primary afferent neurons to capsaicin might be related to a downregulation of the capsaicin/TRPV1 receptor. Changes in TRPV1 protein/mRNA level were investigated with in situ hybridization, quantitative reverse transcription polymerase chain reaction, immunohistochemistry, and Western blot analysis. Our results suggest the involvement of distinct cellular mechanisms in the regulation of the TRPV1 mRNA expression of damaged neurons, specifically triggered by the nature of the injury. The antinociceptive and anti-inflammatory effects of perineurally applied capsaicin involve distinct changes in neuronal TRPV1 mRNA expression and long-lasting alterations in (post)translational regulation.

Product Specifications
SKU :COC84472
AuthorCsaba Szigeti,Péter Sántha and Gábor Jancsó
LanguageEnglish
BindingPaperback
Number of Pages68
Publishing Year2013-05-31T00:00:00.000
ISBN9783659402449
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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