The topic on conversion and utilization of methane were important issues both in chemical industry and environmental purposes. Several technologies including plasma-insisted techniques have been proposed to improve the process involving the activation of methane. The direct conversion of methane to methanol in the presence of energetic species, i.e. ion, radical, electron, and excited molecules, has attracted many experts'' attention in recent years. In this book, the concepts and some applications of plasma to synthesize methanol from methane were briefly discussed. The book contains some recent and important scientific reports in direct conversion of methane to methanol with and without catalyst support.