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Cerebral Subcortical infarcts with Leukoencephalopathy


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

CADASIL is a rare mid-adult onset monogenic form of hereditary cerebral microangiopathy, caused by mutations in the NOTCH3 gene which lead to abnormal extracellular matrix accumulation of granular osmiophilic material (GOM) in the vicinity of vascular smooth muscle cells (VSMCs) causing degeneration and loss of VSMCs in small arteries and arterioles. Clinically the syndrome is manifested as migraine with aura, recurrent subcortical ischaemic events or strokes, subcortical vascular dementia and mood disorders. Diagnosis of CADASIL is established on the basis of results of genetic testing; skin biopsy and MRI. Typical MRI findings are T2 weighted hyperintensities in white matter and the capsula externa, Subcortical lacunar lesions and cerebral microbleeds are seen. Only symptomatic treatment is obtainable for CADASIL.

Product Specifications
SKU :COC60338
AuthorAbdalla Bowirrat,Awni Youssef and Mustafa Yassin
Number of Pages76
Publishing Year12.12.2014
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00