3.5 million people suffer from Retinius Pigmentosa, worldwide. Retinitis Pigmentosa is an eye disease that damages the retina. Retina is the layer of tissue at the back of the inner eye that converts light images to nerve signals and sends them to the brain. Retinitis Pigmentosa can run in families. The disorder can be caused by a number of genetic defects” According to statistical records 3000 RP people live in Sweden and 4000 people are registered in RP Association in Iran, but based on interviews with active RP patients in the Iranian Association for Protection of RPs, it is claimed that in spite of the latter statistics it is estimated that 70000 people suffer from RP in Iran. The main purpose of this research is to investigate efficient factors in life satisfaction of RP patients and to find out their challenges in personal and social life, according to individual, social, structural and environmental barriers. Furthermore, the relationships between these levels of life in order to explain their social oppression and exclusion are explored and discussed .