Worldwide, injuries are the leading cause of mortality and morbidity in children. However in many parts of the world, especially developing countries, there are scarce data to guide the development of effective interventions and policies to prevent the occurrence of injury in children. To investigate the epidemiology of injury in Palestinian school- children, data on injury mortality and morbidity were analyzed using Poisson and logistic regressions. Firearm missiles, road traffic crashes, falls and drowning were the leading causes of injury mortality in the Palestinian children. Being a boy, being a child at younger age, riding a bike, reporting of health problems by the children and involving in risky taking behaviours were factors that found to be associated with the occurrence of serious injury.