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Chlamydia pneumoniae Lung Infection in Two Inbred Mouse Strains


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Infections with Chlamydia pneumoniae have been associated with chronic inflammatory diseases, but the influences of multiple factors are not well understood. A multivariate experimental design investigated the major factors that influence disease, chlamydial lung burden, and transcript levels: i) host genetics, ii) pre-challenge immunity, iii) time after challenge infection, iv) dietary protein content, v) dietary antioxidant content. The combined effects of mouse strain, immune status, and time after challenge inoculation resulted in opposite outcomes for lung disease and elimination of C. pneumoniae, while dietary protein and antioxidant content had little overall influence. A simple best-fit partial least square regression model using day-3 Tim3, GATA3, and arginase 2 transcript concentrations predicted 85% of the day-10 disease and 72% of the day-10 C. pneumoniae lung load. This book has elucidated general mechanisms of chlamydial pathogenesis, and clearly supports the concept that host-dependent levels of early Th1 and Th2 responses, and their balance, significantly correlated with late disease and pathogen load of C. pneumoniae lung infections.

Product Specifications
SKU :COC21917
AuthorChengming Wang
Number of Pages116
Publishing Year3/13/2010
Edition1 st
Book TypeVeterinary medicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-28 00:00:00