Chocolate is highly sophisticated and infinitely more versatile food that is combined to create completely different taste and texture sensations. The objective of the present study is to develop a palatable chocolate formulation of Domperidone and Cetirizine for pediatric administration and to increase a patient’s desire to consume the medication. In this investigation chocolate base is prepared by use of cocoa powder, coco butter, lecithin, pharmaceutical grade sugar. Thereafter drug is incorporated to prepared chocolate base. The medicated chocolate prepared is evaluated for appearance, moisture content determination by digital Karl Fischer titrator, blooming test, drug content determination & drug excipient interaction by differential scanning calorimetry.