The world as we've known it is changing. The impact of globalization and urbanization is felt far and near. Church planters face the daunting task of sharing the Gospel, training leaders, and starting new faith communities in cities with ever increasing economic and international diversity, a constantly evolving urban culture, and widespread cultural influence. The challenges and complexity of global cities is immense. However, the response to these new challenges may be found in principles and strategies that are simple, natural, but yet perhaps counter-intuitive. Nevertheless, they echo the response of missionary voices over many decades. While addressing new complex issues and contexts, the missionary enterprise remains an organic process that leads to life transformation. Organic church planting may provide a pathway for those longing for Gospel movements in the world's leading cities.