Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Cloning, Expression and Purification of kir6.1 in Bacterial system


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days


Check Your Delivery Options

Rs. 3,718

Availability: In stock

  • Product Description

Adenosine-triphosphate-sensitive K+channels [K+(ATP)] are the protein channels responsive to changes in ATP/adenosine diphosphate (ADP) ratio and provide a means to couple movement of potassium ions, to relate membrane potential with cellular energy status. Various subfamilies of K+(ATP) channel proteins, designated as Kir1.0 to 7.0, share significant amino-acid homology (40%) among them. The Kir6.0 subfamily consists of Kir6.1 and Kir6.2 proteins with around 70% amino acid homology. Kir6.1 is widely expressed in tissues, including pancreatic islets, heart, skeletal muscle and brain. K+(ATP) channels are assembled from two different subunits, a Kir subunit that forms the ion-conducting pore and a sulfonylurea receptor (SUR), a member of the ABCC subfamily. Activation of an K+(ATP) channel is known to be an important part of endogenous protective signalling that promotes cellular survival under conditions of metabolic stress. More recently, evidences suggest that activation of sarcolemmal and mitochondrial K+(ATP) channels may promote cellular survival and act as central effector molecules in ischemic/hypoxia preconditioning.

Product Specifications
SKU :COC87052
AuthorAjaz Ahmad Waza and Mahboob Ul Hussain
Number of Pages92
Publishing Year2013-09-19T00:00:00.000
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00