The problem of inadequate post operative pain relief has been recognized for many years and has been the subject of considerable research. A recent concept for the relief of post operative pain has been production of such a preoperative analgesia which should have a reduced incidence of pulmonary, cardiovascular, thromboembolic and other complications with better free mobility. Aim of this study was to compare the efficacies and adverse effects of pentazocine, fentanyl and tramadol as pre-operative analgesics in patients undergoing short surgical procedures with post-operative ketorolac. Patients who received pre-operatively analgesia with fentanyl had been found to have better pain relief for longer duration as compared to those who received pre-operatively tramadol, pentazocine and post-operative ketorolac. Therefore, our work discerns that pre-operative administration of fentanyl 50 µg 15 minutes before surgery in patients undergoing short surgical procedures provides exquisite control of post-operative pain.