The most important skill for all dentists is the ability to provide safe and effective anaesthesia. Over the years different techniques have been developed for achieving mandibular nerve block. The most widely used is Direct Conventional (open mouth) Mandibular nerve block technique. But it has its own drawbacks like anxiety, anatomical variations, separate injection for long buccal nerve etc. However, in patients having limited mouth opening, like in infection and trauma, the importance of Akinosi- Vazirani technique (close mouth) Mandibular nerve block technique cannot be underestimated. Due to limited number of controlled studies estimating the relevant parameters of anaesthesia achieved, it appeared reasonable to study the comparison and clinical efficacy of mandibular nerve anaesthesia by Direct Conventional technique with Vazirani-Akinosi mandibular nerve block technique, by using relatively precise clinical parameters.