Information is the most important element for every business to run. Every industry such as banking, healthcare, telecom, defense, aerospace, education, politics etc. needs information to perform their operations and functional processes. Hence, ‘Information Systems’ is now become most significant tool for industries through which they can manage complex information, make effective policies, set long term goals, and get competitive advantage in the market. This work deals with the attempts to explore the various applications of information systems and their significance in different sectors such as academic institutions, service industries, and law and enforcement agencies. It includes valuable references for students and professionals working in the field of information systems.