This study is an investigation into the discourse of the Catholic Church on the use of condoms in the prevention of HIV transmission. The objective is to assess the preferred discourse among Catholic students in a nursing school. The findings revealed that in principle, students supported the Church?s message of abstinence while in practice they favoured the secular?s message of condom use. Message of "safe sex" from secular institutions, and students? distorted perception of the Church?s teaching on human sexuality undermine students? ability to make an informed decision when dealing with issues of abstinence, fidelity and condom use. The study has generated more information on the Christian-Secular discourse on condom use which is of great help to scholars, students, government, Church and other planners in the country to understand the HIV/AIDS phenomenon better.