Medicinal and Aromatic Plants (MAPs) are among the group of plants that are threatened in Nigeria. The demand for the plant parts is increasing and majority of the medicinal plant products for sale in the markets come from the wild collections. The medicinal usefulness of these plants cut across their use in treating all forms of human diseases and deficiencies. The therapeutic uses of over fifty (50)medicinal plants described were described in this book, in addition to the listing and explanation on close to thirty (30) threatened medicinal plants in Nigeria. In addition, the advantages and disadvantages of cultivating medicinal plants were highlighted. This publication concludes by recommending the cultivation of highly demanded medicinal plants, among many other recommendations necessary for the sustainability of the nation''s diversity and wealth of medicinal plants.