Diabetes (Prameha) : Diabetes is one of the emerging dreadful life style disorders in the present health scenario. The incidence and prevalence of this life style leading to diabetes is increasing at an alarming rate. According to WHO – India has been projected as the country with the fastest growing population of diabetic patients. It is estimated that between 1995 – 2025 diabetic patients in India will increased by 195% This silent killer Diabetes is simply correlated with Madhumeha which was already described in Ayurveda as a „Mahagada?. Various remedies used for the treatment of diabetes are not able to achieve glycemic control effectively. Also, well proved anti-diabetic drugs are known to have adverse side effect. Herbal preparations are preferred therapeutic agents to manage the glycemic control in diabetics because of their fewer side effects. Antidiabetic efficacies of various plants and herbs have been proved scientifically. Mamajjaka(Enicostemma Littorale) used in various Ayurvedic formulations is also used as anti -diabetic agent by the rural folks.