Disease is an abnormal condition affecting the body of an organism. It may be caused by a number of factors. So after accurate diagnosis, appropriate treatment must be given to the patient in order to relieve him/her off his/her symptoms. Corticosteroids are chemically similar to endogenous cortisol which is important in protein,carbohydrate and fat metabolism, maintenance of vascular reactivity and adapting the body to stress. They represent an important therapeutic aid in the management of a range of oral mucosal disease conditions. Like all medications, their successful use depends upon an understanding of the disease process. The purpose of this book is to create awareness among Dental Professionals globally about the role of corticosteroids in treatment of various oro-facial diseases.