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Crystal Engineering of Active Pharmaceutical Ingredients


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  • Product Description

Enhancing the physicochemical properties of solid-state materials through crystal engineering enables optimization of these materials without covalent modification. Cocrystals have become a reliable means to generate novel crystalline forms with multiple components and they exhibit different physicochemical properties compared to the individual components. This dissertation exemplifies methodologies to generate cocrystals of active pharmaceutical ingredients (API’s) based upon knowledge of supramolecular interactions (supramolecular synthons), while focusing on enhanced delivery through in vitro and in vivo processes with both salts and cocrystals respectively. Different multiple component crystalline entities were discovered through traditional solution based techniques and with mechanochemistry involving small amounts of an appropriate solvent, or solvent drop grinding (SDG). Dissolution studies and pharmacokinetic enhancement through optimized oral drug delivery via supramolecular complexes are presented with particular attention to non-covalent intermolecular interactions.

Product Specifications
SKU :COC40035
AuthorDavid R. Weyna
Number of Pages236
Publishing Year8/22/2012
Edition1 st
Book TypeChemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-02-08 00:00:00