The questions of whether medicines discovered today are safer, more efficacious, and more affordable than generic medicines or medicines that are centuries old could be answered “no” for most of the modern medicines. If so, then it is logical to revisit and revive these age-old medicines for the welfare of mankind.Curcumin is an important nutraceutical obtained from the root of the plant Curcuma longa Linn (family Zingiberaceae), is a perennial herb that has enormous potential for a variety of diseases, higher safety margin than the synthetic drugs and is cost effectiveness. Despite having wide spectrum of pharmacological actions, the medicinal properties of curcumin cannot be utilized due to its low in vivo bioavailability. Therefore in view of the foregoing, there is an extensive need for such combinatorial extracts which may enhance bioavailability of oral curcumin by inhibiting the enzymes responsible for the metabolism of curcumin. In the present investigation, Safety and Pharmacological evaluation of Combination consisting of Curcumin with piperine and quercetin in experimental animals was carried out.