Dengue is the most prevalent mosquito-borne viral infection worldwide. Over half of the world’s population live in areas at risk of dengue infection. The disease is transmitted principally by Aedes spp. mosquitoes. Dengue Outbreaks were recorded in all countries of the Indian Subcontinent with Pakistan, India, Bangladesh and Sri Lanka resulting in huge number of cases and deaths. It is a disease caused by four serotypes of a same virus i.e. DENV1, DENV2, DENV3 and DENV4. In all major outbreaks, DENV2 and DENV3 were recorded as dominating and disastrous serotypes in the region. Climate is a vital factor influencing DF outbreaks; temperature, humidity, rainfall and flood play a fundamental role in DF outbreaks, as providing optimum conditions for vector population growth.Presently, prime prevention of dengue is possible only with vector control and personal protection from the bites of infected mosquitoes.