Cyanide is widely distributed in the ecosystem and has been linked with lethal effects in animals as well as humans. Cyanide toxicity may be the result of intake from food sources, environmental pollution, intentional ingestion, chemical warfare, occupational exposure, homicide, and sometimes through the use of drugs like nitroprusside and laetrile.Cyanide intake has been linked to central nervous system syndromes and thyroid in animals as well as humans. This book covers the following aspects. 1) cyanogenic potential of various sorghum species. 2) cyanide levels in blood samples of cattle, buffaloes, sheep and goats feeding on cyanogenic plants. 3)new simple, reliable and inexpensive assay to determine CN? levels in blood samples. 4)efficacy of various antidotes against cyanide toxicity. 5) effects of cyanide toxicity on hematological and biochemical panel. 6) postmortem lesions and histopathological changes associated with cyanide toxicity in various organs. 6) alterations in tissue oxygenation and metabolic variables during acute cyanide toxicity.