The book details an insight in the pathological mechanisms of experimental malaria by comparing the patterns of cytokine responses in mice. The study is intended for scientific community dealing with infectious diseases. In the book different courses and outcomes of cytokine excess or deficiency have used to deduce instances of malaria infection. The cytokine levels for IFN-γ and TNF-α appears to coincide with the development of CM. The dual roles of the cytokines in pathogenesis by induction of apoptosis has been discussed.