Moss - the first land plant and an ideal candidate for evolutionary studies. in vitro and in silico techniques offer vital insights into evolution and conservation of proteins among land plants. Milestones of biological research like the first description of sex chromosomes in plants, the continuity of chromosomes during mitotic cycle, non-Mendelian inheritance and introduction of UV-mutagenesis to genetic research, were first introduced by scientists working on bryophytes. In this work, an attempt has been made to study Cytosine DNA Methyltransferases in Physcomitrella patens. The availability of the genome sequences and related genomic and genetic resources have contributed to the emergence of Physcomitrella as a model system for studying important biological functions.