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Degradation Study Of Tenofovir Disoproxil Fumarate


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  • Product Description

Stability indicating RP-HPLC method for estimation of Tenofovir Disoproxil Fumarate in the presence of its degradation products during conduction of stability studies on the pure drug which was carried out by using a mobile phase comprising ACN: Water (70:30 v/v), pH adjusted to 4.5with OPA,, at flow rate of 1 ml/min. with UV detection at 260 nm. The concentration of TDF was found sufficient for obeying Beer’s law over a range of 10-90?g/ml. In the present study, the drug was subjected to acid (0.1N HCl and 0.01N HCl), and alkaline (0.1N NaOH and 0.01N NaOH) hydrolysis. TDF was found to be more sensitive to alkaline hydrolysis and it was somewhat stable to acidic conditions. The degradation kinetic of Tenofovir Disoproxil Fumarate is governed by hydrolysis of the isopropyloxycarbonylmethyl moiety. Degraded product formed is monoester. The % degradation in both acidic and alkaline condition is calculated by UV-Spectrophotometric and RP-HPLC method.

Product Specifications
SKU :COC60053
AuthorShubhangi Sutar,Shitalkumar Patil and Sachin Pishavikar
Number of Pages68
Publishing Year28.07.2014
Edition1 st
Book TypeReal analysis, real variables
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00