In recent years science and technology have made big steps, allowing us to greatly improve knowledge in basically every aspect of biology, culminating in the mapping of the human genome. However, although the brain is considered our most vital organ, the essence of personality and memory, much about the human brain still remains a mystery. Morphological analyses seemed to support the idea that senescence was accompanied by neuronal loss, particularly evident in the cortical and hippocampal structures. The work embodied in this book was carried out to find out whether administration of neuroprotective and anti-aging compound dehydroepiendrosterone (DHEA) at different ages of the animals prevents the delay of biochemical, molecular, structural and physiological alterations know to the neurological disease associated with aging. Based on study, the DHEA beneficial effects seemed to arise from their antioxidative, antiobesity, antilipofuscin and antilipidperoxidative actions.