Dengue is the most important mosquito borne disease because of its escalating spread affecting about 50-100 million people each year. The principal dengue vector Aedes aegypti is now well established in almost countries of the tropics and subtropics with estimated 3.6 billion people at risk of contracting dengue. In recent years, the rapid expanding of secondary vector A. albopictus to the uninfested regions including Europe has increased its concern for inflicting dengue. Nepal experienced the first indigenous transmission of dengue virus in 2006. This book furnishes the clear insights of the status of dengue burden in some western lowlands of Nepal. The acute infection of dengue virus was assessed by serological assay and the high positivity to dengue virus underscores the co-circulation of dengue viruses in the terai region, hinting possible epidemic of DHF. The book could be useful to the researchers, university students and other stakeholders to understand the distributions of the disease in the newly affected country and realize the necessity of prospective research avenues to better understand the disease dynamics and vector ecology for crafting effective control measures.