The denture adhesives are used to improve retention, stability, function and comfort of the patient. Denture adhesives are one of the controversial topics in the field of Prosthodontics. This in vivo quantitative study was conducted to determine and assess the effect of different type of denture adhesives on the incisal bite force of complete denture wearers, until the dislodgement of upper denture, using pressure transducer. The work is useful for anybody and everybody who fabricates dentures, one who wears it and also who manufactures Denture Adhesives. It promises meaningful information to dental undergraduates in clinics, interns, general dental practitioners, post-graduates and research scholars. It will be helpful to dental academicians and clinicians and Denture Adhesives Manufacturers.