Providing drinking water has been one issue for the world population. By 2025 this issue is threatening around three billion people who are hard to access clean potable water. The provision of potable water has become a challenge. The ability to produce potable water economically is thus the primary purpose of seawater desalination work. Reverse osmosis (RO) and multi-stage flash (MSF) for desalination are already used, but they are more costly than potable water produced from fresh water resources. As an alternative to RO and MSF, this work provides information for desalination system with the cost analysis. This investigates a high-efficiency mechanical vapor-compression distillation system that employs an improved water flow arrangement. Greater efficiency of the vapor compression system is achieved by connecting multiple evaporators in series, rather than the traditional parallel arrangement. This information should help encourage an exchange of information in open forum, and should be a benefit to representatives from engineering and economics that have an eye to acquire both economical and technical basic knowledge in the field of mechanical-vapor-compression distillation.