In this book extensive analysis of thermoelectric refrigerator is done startng from the introduction of the technology including previous research's made in this area. Comparison with different cooling technoligies is made on the thermodynamic platform and material's for the thermoelectric refrigerator are suggested. Comparison of the performance of the thermoelectric refrigerator based on different pair of thermoelectric material's is done. Thermal design is carried out based on the various thermodynamic relations. Analysis of the design is done by varying the various affecting parameters and data is compared with the practical data provided by manufacturer. Optimization is carried on various platforms and design charts are prepared which will be helpful in predicting the performance of the system and finally future scope of the technology betterment is also discussed.