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Design & Evaluation of Orally Disintegrating Tablet of Antiemetic Drug


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The bitter taste of the drug was masked by Kyron T 114, a weak cation exchange resins with the method of ion exchange resin complexation, Which was prepared by the batch technique and various parameters (i.e. resin ratio, pH, Temperature, swelling time and stirring time) was optimized to successfully formulate the resinate into ODT and it was confirmed by FTIR and DSC study. ODTs were produced by directly compressing a mixture containing superdisintegrant, diluent, glidant, lubricant, and sweetener. In preliminary trials selection of superdisintegrants (i.e., crosspovidone XL 10, cross carmellose sodium and sodium starch glycolate) and Selection of diluent (i.e. mannitol SD 200, Avicel pH 102 Avicel pH 112, Starch and pregelatinized starch) were made. The cohesive force of mannitol increase wetting time and Disintegration time so drug release was delayed. 32 factorial design was applied in which superdisintegrant and diluent ratio were taken as independent factor and disintegration time and wetting time were taken as response.

Product Specifications
SKU :COC30964
AuthorPoraskumar Patel,Kunal Patel and Bhavanaben Patel
Number of Pages232
Publishing Year2012-01-08T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00