In this book we consider that methodology Six Sigma is a well-known concept who means the perfection: A process of production to three sigma makes 3.4 defaults/million unit, whereas six sigma means for us the perfection. We used it now to mean type of specialized training aiming at the attack of very high objectives for processes improvement. Six Sigma is a method of continuous improvement and elimination of non quality, passing by six stages or cycle DMAIC: To define, Measure, Analyze, Innovate and Control carried out by a team of project. In This book we propose a new practice of Six Sigma for reduction of the number of conformities and minimization of the number of complaints customers for KITAMEUBLE industry. Secondly we suggest a new practice of Six Sigma for reduction and optimisation of non-conformity for Aluminium Company. Finally we use the methodology Six Sigma for Reduction and optimization of water consumption for Coca Cola industry.