In dynamic competitive business environment the banks advance their intermediary role to facilitate the investors and the borrowers with an aim to sufficiently provide the justifiable needs of its society, stakeholder, and utmost for their survival. To meet this primary objective, banks utilize their resources effectively and enhance their operating efficiency to maximize their profits. There are many factors that exhibit drastic effects on the profitability of banks. This includes controllable (Bank specific and Industry specific) and uncontrollable (macro-economic) factors. This study will highlight the priorities of the significance of controllable and uncontrollable determinants of profitability. This study endeavors to construct numerous contributions so as to extend more inclusive and rigorous studies on the profitability of the banking sector.