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Develop Buccoadhesive Gel for Treatment of Oral Submucosal Fibrosis


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

In the present work, an attempt was made to formulate buccoadhesive gel for the treatment of oral submucousal fibrosis. The aim was to assess the influence of type and concentration of gelling agents: Carbopol 934p and sodium carboxy methyl cellulose on the quality attributes of buccoadhesive gel. All the proposed five buccoadhesive gel formulations were prepared. The prepared gels were evaluated and In-vitro release of metronidazole and lycopene at 240 min from buccoadhesive gel determined.The release of lycopene not satisfactory from optimized gel formulation, to increase the release of lycopene we can be use release modifier/modifiers are incorporated in to the formulation. It could be promising local alternative treatment of OSF and could be subjected further In-vivo study in rats by inducing OSF then after treating with optimized preparation, skin irritation test and stability study will be performs. In conclusion 1% Carbopol: 3% SCMC can be use as vehicle for buccoadhesive drug delivery system to the oral cavity because of their good buccoadhesion, spreadability, extrudability and release profile reported.

Product Specifications
SKU :COC60536
AuthorPoonam Kumari,Kamal Singh Rathore and Roshan Israni
Number of Pages80
Publishing Year12.12.2014
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00
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