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DEVELOPMENT AND CHARACTERIZATION OF ROSIGLITAZONE NANOPARTICLES

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 
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  • Product Description
 

Nanoparticles have gained much attention as a promising drug delivery system due to their unique properties. Rosiglitazone maleate, an antidiabetic agent, acts as a highly selective and potent agonist for PPAR receptors in target tissues for insulin action. In spite of its high efficiency, side effects limit the clinical use. To reduce the side effects of conventional dosage form, rosiglitazone loaded nanoparticles have been formulated. Nanoparticles were formulated by gelatin and chitosan via double desolvation and ionotropic gelation technique respectively, & subjected to photon correlation spectroscopy, transmission electron microscopy & encapsulation efficiency studies. These studies favorably revealed that the mean particle diameter of optimized formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical morphology. The optimized formulation demonstrated favorable in vitro prolonged release characteristics with zero order, diffusion and erosion mechanisms. Nanoparticles also showed excellent stability. Hence, the designed delivery system can be fine tuned on the depending clinical applications.

Product Specifications
SKU :COC94584
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
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