Rheumatoid arthritis (RA) is an autoimmune disease that results in a chronic, systemic inflammatory disorder that may affect many tissues and organs. It can be a disabling and painful condition, which can lead to substantial loss of functioning and mobility if not adequately treated. Naproxen is effective for the usual rheumatologic indications. But, the drug is practically insoluble at low pH and freely soluble at high pH. So, the drug release was controlled by formulating it into a sustained release matrix system with the help of hydrophilic polymers. The current work focuses on the development and optimization of Naproxen 800mg tablets using surface response methodology. This work will be useful to those research scholars who are willing to their research on sustained release tablets using Factorial design.