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Development and Validation of Periodontal In situ Gel of Articaine

 

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  • Product Description
 

Articaine hydrochloride, a water soluble local anesthetic, is administered by block/infiltration anesthesia during the treatment of periodontitis. The pain, associated with injection of local anesthetics, can be overcome by the use of in situ gel forming system of local anesthetics. The system is a low viscosity fluid at room temperature and rigid elastic gel at body temperature, undergoing in situ sol gel transition.The present work describes the formulation, characterization and preliminary drug release studies of muco-adhesive formulations containing articaine, polaxomer 407 as the thermoreversible gelling agent in combination with hydroxypropylmethylcellulose (HPMC) and Carbopol 934P, as a muco-adhesive agent. Each formulation was characterized in terms of gelling temperature, viscosity, muco-adhesive force, spreadability, drug release.The gelling temperature varied with the polymer concentration and the presence of drug.The in vitro and ex vitro permeation studies indicated the sustained drug release for a 7-h period.Prospective Process Validation was also performed on formulations.The developed system is a viable alternative for the conventional injectable dosage form.

Product Specifications
SKU :COC31180
AuthorSarfraz Khan Aslam Khan,Alpana Pradeep Kulkarni and Simmi Shabbir Malik
LanguageEnglish
BindingPaperback
Number of Pages136
Publishing Year2012-07-11T00:00:00.000
ISBN978-3659270222
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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