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Marketed By :  VDM Verlag Dr. Müller   Sold By :  Kamal Books International  
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  • Product Description

A simple and rapid HPLC assay procedure has been developed and validated for the quantitative determination of metronidazole benzoate from commercially available preparations. The HPLC system was developed based on the BP 2007 monograph of metronidazole suspension. However the various parameters were modified according to column and equipment available. The HPLC conditions used were, column: C18, detection: UV at 254 nm; injection volume: 20 ?l; mobile phase: methanol and de-ionized water (13:8, v/v); flow rate 1.0 ml min?1. The procedure separated metronidazole benzoate, in an overall analysis time of about 10 minutes with metronidazole benzoate eluting at about 7.7 minutes. The new method was evaluated by different validation parameters like specificity, sensitivity, accuracy and precision. The procedure provided a linear response over the concentration range 50–1000 ?gml?1.The metronidazole raw material as well as different commercially available suspensions containing metronidazole benzoate have been analysed by this method. The results obtained were accurate and precise showing no interference by the excipients in the products.

Product Specifications
SKU :COC22412
AuthorShafique Hussain,Syed Saeed-ul-Hassan and M. Usman
Number of Pages112
Publishing Year2010-12-11T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-28 00:00:00