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Development of Compression Coated Colon Targeted 5-Fluorouracil Tablet


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The purpose of this study was to develop and evaluate a drug delivery system in vitro based on a compression coated tablet containing 5-fluorouracil (5-FU) in core and pectin Hydroxypropyl Methylcellulose (HPMC) mixture in coat layer. The main reason for selecting pectin was its biodegradation in colon by colonic flora. On other hand, high molecular weight HPMC increases mechanical strength of tablet coat around a drug core during its transportation in gastro-intestinal tract. Multiple regression analysis with two way ANOVA revealed that both factors had statistically significant influence for the response studied (P<0.05). Results of Tukey test showed the relative contribution of each level of different factors for the response studied.

Product Specifications
SKU :COC31460
AuthorMukesh Patel,Kanu Patel and Natvarlal Patel
Number of Pages112
Publishing Year8/20/2012
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00