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Development of Sustained Release Tablet containing Antidiabetic Agent

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The overall objective of the present work was to develop an oral sustained release Metformin tablet prepared by direct compression method using Hydroxypropylmethyl cellulose and Xanthan gum in different proportions. Nine formulations (T1-T9) were prepared. All the batches were evaluated for thickness, weight variation, hardness, and drug content uniformity and in vitro drug release. The dissolution study was performed as per USP-32 NF-27. The initial burst release was minimized by optimizing the concentration of xanthan gum. Then the concentration of HPMC was varied, keeping the concentration of xanthan gum fixed. From the dissolution study of nine batches, T8 was found to be the optimized batch capable to sustain the drug release for 10 hrs as it follows the dissolution parameter mentioned in USP-32 NF-27. The drug release kinetics shows that the T8 batch followed first order kinetics.

Product Specifications
SKU :COC84907
AuthorRajat Kharche
LanguageEnglish
BindingPaperback
Number of Pages124
Publishing Year2013-08-25T00:00:00.000
ISBN9783659274596
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00