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Diagnostic methods of ANCA


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Autoimmune diseases occur when physiological tolerance to self-antigens is lost and thereafter, human body can not discriminate between self and non-self tissue. In autoimmunity, production of different auto-antibodies result in variety of pathologic manifestations. Auto-antibodies are hallmark of both systematic and organ specific autoimmune diseases. Among various autoantibodies, anti-neutrophil cytoplasmic antibody (ANCA) is a useful diagnostic tool for auto-immune glomerulonephritis. There are many techniques used for the detection of ANCA level. Here, we want to introduce some common techniques i.e. ELISA, IFT, cytogram and flow cytometer. Objectives: Current study was designed to determine sensitivity & specificity ANCA (p-ANCA and c-ANCA) of ELISA method. Results: ELISA is most sensitive method for c-ANCA and most specific method for p-ANCA. Diagnostic value of ELISA for both parameters c-ANCA & p-ANCA is same 95.31%. Conclusion: ELISA is sensitive as well as specific method for the detection of ANCA. Besides that indirect immunoflorecent technique (IIF) remains the gold standard method for the detection of ANCA (c-ANCA & p-ANCA).

Product Specifications
SKU :COC23765
AuthorMaria Arif and Taha Arif
Number of Pages68
Publishing Year2012-06-05T00:00:00.000
Edition1 st
Book TypeLaw
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-28 00:00:00