Over 3 decades after dielectrophoresis (DEP) was explored and defined, it has already been successfully applied in separating, trapping, and handling bioparticles in micro and sub-micro scale biotechnology. However, nearly all of DEP applications are concentrated on the analysis and manipulation of particles in sub-micron and micron scaled systems with flow rates below milliliters per minute. So far, almost none is known in process engineering for DEP in a scaled up application at flow rates of liters or even cubic meters per minute. The research described in this book is the first that attempts to scale up DEP application. With the research results described in this book, the feasibility of the DEP technique application in separation is verified. The proved high selectivity and controllability of DEP technique in separation application grand DEP a very promising prospect in separating, trapping, handling and manipulating particles.