Girls and women are discriminated in all spheres ? social, political and economic. Education is not an exception; it is also dominated by boys and men. The socialization process at home and school orient girls and boys on specific gender roles and norms. Thus gender difference begins from the two major areas where the girls and boys spend important period of their life as children and adolescent. However, there has been little research examining discrimination against girls at school and home, and their perceptions and responses in Nepal. This study explores various dimensions of discrimination as well as the experiences, perceptions and responses from the actor''s perspective. This qualitative study adopts various theoretical stands to analyze the major themes of the study. The study particularly emphasizes the need of change on contemporary micro level situation that of classroom and home; thus targets the major actors like boys, teachers, parents, girls among others. On the broader level, it aims policy makers and stakeholders to amend and formulate national level policies specifically on discrimination, domination and harassment against girls.