In recent year the rate of death caused by the cardiac illness attract the preoccupation of many researchers for developing relevant applications which will resolve the existing problems of this domain. As a subfield of artificial intelligence the case based reasoning and multi-agent systems which propose a solution of much kind of complex problems in all domains. This book contains a useful introduction to the cardiology domain, a deep survey about the case based reasoning and multi-agent systems and a professional description about the contribution by considering the engineering aspects of the application. This book is addressed for students, researchers and professional engineers who are motivated by health science applications. The reader of this book will capitalize many theoretical and practices aspects from both domains cardiology and artificial intelligence.