Now a days herbicides effect on targeted and non-targeted organisms increasing commonly and burning point for discussion. This herbicidal effect on non-targeted crops is one of the most serious environmental problems and limiting the plant productivity and challenging human health. Wheat, the king of cereals, is used as major food source all over the world. The tremendous growth of population and demand of food security for the growing population, need to increase the yield in very less time and in limited land without weeds. Modern agriculture means production of cereal crops without weeds by application of herbicides for wheat as well as other crops. The excessive use of herbicides to increase the yield in crop field enhances the level of toxicity in the environment. High availability of herbicides in the soil, drainage, plant system and other organisms make them potential toxic substance and adversely affecting the morphology, physiology, biochemical and cytological injuries. Herbicide application requires permanent investigations, tradition and long term prediction, to enable not only good business for production but high productivity, high value food obtainment.