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Drug Designing:Homology modeling of PKC inhibitors


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Computer Aided Drug designing is the approach of finding new drugs, based on the biological targets (the protein). Protein kinase C (PKC) is an isozymes and a subclass of threonine/serine kinase family of proteins. it is known to be an important class of enzymes in cell signaling and as drug targets, cell cycle control has led to detailed structural and functional studies in various eukaryotes, and hence to the synthesis of specific chemical inhibitors for managing disease.Homology modeling of Protein kinase C delta predicts a 3-D structure protein.Homology models were generated by software tool called “MODELLER”.Phosphorylation by protein kinases is a central theme in biological systems. Activity of protein kinases will be stopped by blocking the phosphorylation. ATP docking with protein kinase C is the main step in this research work and was successfully done. The results of ATP docking were compared with another protein in which ATP was already docked. Then inhibitors of protein kinase C delta were retrieved and converted into pdb file format, their docking with protein was also carried out by AutoDock Vina.

Product Specifications
SKU :COC36392
AuthorWaseem Akhtar Shamshari,Dr. Umar Hassan Khan Niazi and Ms.Ambreen Ayub
Number of Pages84
Publishing Year9/27/2012
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00