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Drug Discovery of Inflammation through Complement receptors


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  • Product Description

The purpose of inflammation is to protect the host against microbes, to repair injuries, and to contribute to the removal of apoptotic cells or immune complexes, when it becomes excessive and chronic, this process can contribute to several pathologies including the development of cancer.The study of complement system describes the role of complement proteins in the regulation and synchronization of an acute inflammatory reaction, which aims to eliminate pathogens and clear damaged cells and proceeds with obvious benefit for the host, And also the contribution of complement to the pathophysiology of selected diseases. To illuminate the nature of complement receptors C5aR and C3aR, and the nature of their binding correspondingly, need the building of homology models and a stepwise structure refinement of the built models through molecular dynamics simulations. In this book, we focus on the homology modeling of Complement receptors to provide vast structural features. Moreover, validation of the developed models through available mutation data. Application of docking methods against these models is necessary for virtual screening to detect novel ligands.

Product Specifications
SKU :COC97352
AuthorMadhu Babu Battu
Number of Pages68
Publishing Year2011-03-30T00:00:00.000
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandNot defined
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00
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