This study has shown that exercise significantly improves insulin sensitivity, decreases insulin resistance and improves adipokines which get stimulated due to accumulation of fat in adipocytes and more so because odd deposition of visceral fat than skeletal muscles. Exercise has shown the significant effect on certain clinical and anthropometric parameters i.e. weight, BMI, DBP in Diabetic patients and their First Degree Relatives(FDR's). Exercise has shown the significant effect on biochemical and metabolic parameters in terms of decrease in total serum insulin level, HOMA-IR, HOMA-%B, resistin level, total cholesterol, LDL and triglyceride level whereas increase in HDL level, HOMA-%S and leptin level in Diabetic group whereas in FDR’s of T2DM similar trends were noticed except decrease in leptin concentration and no change in total cholesterol level. With reference to prakriti(personality), kaphaja individuals have shown more improvement than pittaja prakriti(personality) individuals.