Oedema is the presence of excess fluid in the body tissues (Guyton & Hall, 1997). During long air flights, blood pools in the body tissues due to decreased muscle movement. This causes bilateral ankle oedema and results in an increased risk of deep vein thrombosis as well as discomfort to the passengers after their flight (Hope et al., 2001). Hamamelis virginica is clinically indicated as homoeopathic remedy which acts upon the venous system (Nash, 2002). Apis mellifica, Apocynum cannabinum, Natrum muriaticum and Natrum sulphuricum are all homoeopathic remedies used in the treatment of oedema. This study aims to ascertain the efficiency of the Homoeopathic complex formula, Hamamelis virginica 30CH, Apis mellifica 6CH, Apocynum cannabinum 6CH, Natrum muriaticum 6CH and Natrum sulphuricum 6CH in the treatment of swelling (bilateral oedema) in the lower extremities during and after long flights.