Soy milk is rich in Isoflavones content and it has been claimed to relieve many of the symptoms related to menopause. In this study the effect of soy milk (Isoflavones) on CRP and Hcy were explored in response to intake of soy milk. It was an un-blinded open ended trial where 36 women, under a randomized cross-over design. Serum glucose (p=0.009), triglycerides (p=0.008) and NEFA (p=0.013) were significantly lower at endpoint compared to the baseline values. On logistic regression analysis with CRP as the dependent variable and age, BMI, WHR, lipid profile and HOMA%B as the independent variables, there was a significant negative association between CRP and HOMA%B [?=-0.352 (95% CI: -0.021-<0.001), p=0.043] at baseline and at end point [?=-0.360 (95% CI: -0.017-<0.001), p=0.041]. At endpoint Hcy showed significant negative association with HOMA%S (?=-0.521 [95% CI: -0.157-(-0.019)], p=0.041) and HOMA IR (?=-0.382 [95% CI: -1.111-(-0.001)], p=0.050). Soy Isoflavones have beneficial effects on hyperglycemia and dyslipidemia among postmenopausal women and the effects are probably mediated through lowering of insulin resistance and chronic subclinical inflammation.