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Effect of Plant Extracts on RNA Expression Profiles

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Diabetes is a major public health problem. The new therapies developments that are able to improve glycemia management, cure diabetes and even protect from it are of great interest. This study investigated the effect of selected plant extracts on the Insulin 2 gene expression profile against STZ- induced pancreatic cell damages. M.charantia extract showed the highest value of total phenolic content, antioxidant activity and total flavanoid content compared to M. citrifolia and P. speciosa extracts. Expression of both GAPDH as the reference gene and Ins2 gene as the target gene was measured by SYBR Green I fluorescence; melting curves and agarose gel electrophoresis were used to verify the specificity of gene (Ins2) for diabetic rats treated with M. charantia extracts expressing fold differences of 32 fold expression compare to the diabetic control rats only. This study report the preliminary study of the effect of plant extracts on the pancreatic cell insulin gene expression profile. The results represent an important step toward improved understanding of the regulation of insulin secretion on insulin 2 (Ins2) genes.

Product Specifications
SKU :COC97396
AuthorRuzaidi Azli Mohd Mokhtar,Valentino Milton Junior Gumbilai and Wilson Yong Thau Lym
LanguageEnglish
BindingPaperback
Number of Pages88
Publishing Year2011-02-02T00:00:00.000
ISBN978-3844301724
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00