This book is a research work on effects of smoking on Total Serum Cholesterol level in smokers. Due to harmful and even mortal effects of smoking, the factors affecting the health of smokers were estimated and statistically analyzed. Smokers, from district Peshawar, Pakistan were analyzed for its total serum Cholesterol level. The total serum cholesterol level was related with the brand and the No. of cigarettes smoked per day, age of subjects and duration of smoking. Statistical analysis shows an association between smoking and total serum cholesterol level.